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How Gut Bacteria Affect Blood Sugar

Dr. Bahar Amin, MD.

Gut bacteria significantly influence blood sugar levels through various mechanisms:

  1. A study on obese mice revealed that gut bacteria can improve blood glucose control and insulin sensitivity after receiving a specific bacterial extract, indicating that bacteria may have a therapeutic potential to engage innate immunity for better metabolic outcomes (Duggan et al., 2021).

  2. Research on humans and animals has consistently shown that changes in the gut microbiome composition can exacerbate metabolic diseases like type 2 diabetes by affecting host metabolism, inflammation, and glucose homoeostasis (Kyriachenko et al., 2019).

  3. Dysbiosis, or imbalance in the gut microbiota, has been linked to poorer blood glucose control and increased diabetes symptoms, demonstrating the potential of targeting specific bacterial strains for therapeutic purposes, such as with Lactobacillus casei CCFM419 (Wang et al., 2017).

  4. High-fiber diets promoting the growth of short-chain fatty acid (SCFA) producing gut microbes have been found to improve blood glucose control and increase insulin sensitivity, highlighting dietary interventions as a practical approach to modulate the gut microbiota for better diabetes management (Zhao et al., 2018).

These findings suggest that manipulating gut bacteria through diet, probiotics, or other interventions may be an effective strategy to improve blood glucose control and reduce the risk of diabetes.

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